Integrative Physiology Group

Our research

We focus on integrative physiology during environmental stress, including exercise, altitude exposure, and cold temperatures. We are interested in understanding human performance in extreme environments. A particular emphasis has been put on the cardiovascular and respiratory physiology associated with apnea and breath-hold diving, to better understand how the human body can cope with a lack of oxygen. This emphasis is quite unique for the group. We have performed studies involving various forms of “acute” exposures, as well as long-term training studies. We perform experiments both in controlled laboratory settings and in the field, the latter allowing “real-life” conditions to be observed. Healthy, human subjects are primarily used as volunteers in the studies. Today, breath-hold diving has evolved into a competitive sport. We have connections with “elite apneists”, allowing us to explore the physiology and risks associated with the limits of human performance in the water.

Aims

• Understand cardiorespiratory responses during environmental stress, including the effects of training

• Identify stimuli for spleen contraction and the associated release of red blood cells from the spleen reservoir

• Identify risks associated with advanced breath-hold diving and how these can be addressed

• Elucidate factors linked to immersion pulmonary edema (and "squeeze"), including how recovery can be affected

Impact

This is basic research, furthering the understanding of integrative cardiovascular and respiratory physiology, as well as the limits of human performance in extreme environments. This understanding is applicable in several clinical circumstances in which breathing or normal circulatory functions are impaired, such as sleep apnea, perinatal asphyxia, and drowning.

How our research contributes to CoPARLU

We have long experience working with human subjects, using non-invasive techniques for recordings of cardiorespiratory variables. We are open for collaborations, e.g. if the equipment is of interest; including, but not limited to, hemodynamic monitoring system, laser-Doppler flowmeter, ultrasound system, pulse and regional oximeters, open-circuit spirometry, and Monark ergometers.